Tuesday, March 15, 2011
Tuesday, November 30, 2010
AOR Coenzyme Q10 & AOR CoQ10 Plus
AOR Coenzyme Q10 & AOR CoQ10 Plus
Coenzyme Q10 is a fat-soluble, crystalline compound with a Molecular weight of 338.44 Daltons. Co Q10 functions as a co-enzyme in the energy-producing metabolic pathways of every cell of the body with a powerful antioxidant activity.
Biological functions
The fact that Co-Q10 is able to accept electrons in such a ubiquitous manner means that that it can serve several key biological functions pertinent to human health. These include:
The Generation of ATP
Co Q10 is critical in generating the synthesis of ATP (or adenosine triphosphate, the energy "currency" of all cells). This process takes place in the mitochondria and involves an intricate and complex cascade of enzymatic reactions called the "electron transfer chain". Indeed, Co-Q10 is most notably found in the inner membrane of the mitochondrion.
Acts as a Redox agent
AOR Coenzyme Q10 keeps other antioxidants (e.g. vitamins E and C) in their reduced active states. For example, as vitamins C and E perform their functions as antioxidants, they themselves become oxidized. Since these vitamins are active in their reduced forms, AOR Coenzyme Q10 recharges them (reduces them) to their active states by accepting electrons.
Antioxidant activity
Biological oxidation is a ubiquitous event that occurs continually in the body, causing havoc and numerous pathological conditions. Oxidation results from the breakdown of oxygen molecules as they combine with other molecules in the body. Such oxidation can be the result of the body's normal metabolism of the foods we eat, or it can occur in the body as a result of external forces such as exercise, radiation, pollution, alcohol or heavy metal intoxication, infections etc. The resulting free radicals are highly reactive molecules, which interfere with enzymatic reactions and cause disruption of cell membranes and even DNA. Co-Q10 has a strong ability to give up electrons quickly and thus acts as a powerful antioxidant against free radicals, and affords protection against LDL oxidation, which is a pivotal step in the cause of atherosclerosis. Co-Q10 also stabilizes cell membranes and platelets.
The use of AOR Coenzyme Q10 as adjunctive therapy in the treatment of heart failure goes back decades. In fact, Co-Q10 has been approved as a drug in Japan for the treatment of congestive heart failure since 1974, with a number of other nations following suite. Placebo-controlled studies to date with Co-Q10 (including one study conducted in Italy which included 2,664 patients with congestive heart failure) have produced what scientists call 'significantly positive results'. These results include diminished levels of fatigue, chest pain, dyspnea and palpitations. Treatment with Co-Q10 was even able to restore normal heart size and function in some patients - primarily those whose onset of congestive heart failure was relatively recent.
There have also been many studies examining the effect of Co-Q10 as an addition to standard medical treatments, particularly those pertaining to hypertension and other manifestations of cardiovascular disease. When Co-Q10 was added as a concurrent treatment alongside the standard drug therapies for these conditions, the result was a significant reduction in the required use of the aforementioned drug therapies in order to alleviate the conditions in question.
Energy and Exercise
CoQ10's antioxidant and membrane stabilizing abilities have been shown to protect skeletal muscle cells from injury. A recent study found that young men training in the intense Japanese sport Kendo had lower serum activity of creatine kinase and lower serum myoglobin concentrations when they were given AOR Coenzyme Q10 supplements. These two markers are associated with skeletal muscle damage, indicating that AOR CoQ10 Plus reduces exercise-induced muscular injury.
Another recent study tested the effects of AOR Coenzyme Q10 on exercise-induced fatigue. In this double-blind, randomized, placebo-controlled, three crossover design, 17 healthy subjects were given 300 mg CoQ10 for a week before performing a workload trial on a bicycle ergomerter to induce fatigue. To test their physical performance, they performed non-workload trials at maximum velocity for 10 seconds at 30 minutes and 210 minutes of the fatigue-inducing trial. The study found that the decrease in physical performance due to physical fatigue was inhibited in the CoQ10 group compared to the placebo. Also, CoQ10 alleviated the sensation of fatigue compared to the placebo group.
Ensuring Absorption
A critical point to remember is that Co-Q10 is fat-soluble, and that absorption of AOR Coenzyme Q10 has always been a challenge. In fact, well over 60% of orally consumed AOR CoQ10 Plus is excreted in bowel movements and its absorption is not only variable but also dependent on food intake, particularly the lipids present in the food. Absorption is lower when Co-Q10 is consumed on an empty stomach and higher when taken with food that is comprised of high lipid content. In order to overcome this potentially serious impediment to absorption, AORTM has introduced AOR CoQ10 Plus. AOR CoQ10 Plus provides a potent 100mg of Coenzyme Q-10 (ubiquinone) in a softgel comprised of a superior lipid-based delivery system to ensure maximum absorption.
Complications
None reported. Shown to be useful with Beta-blockers, psychotropic drugs including phenothiazines and tricyclic antidepressants. A 1994 Lancet study reported 3 cases where Co Q10 reduced the effect of coumadin. No other cases have been reported. It may be wise to monitor the prothrombin when supplementing with Co Q10.
References
Mizuno K, Tanaka M, Nozaki S, Mizuma H, Ataka S, Tahara T, Sugino T, Shirai T, Kajimoto Y, Kuratsune H, Kajimoto O, and Watanabe Y. Antifatigue effects of coenzyme Q10 during physical fatigue. Nutrition. 2008;24:293-299.
Kon M, Tanabe K, Akimoto T, Kimura F, Tanimura Y, Shimizu K, Okamoto T and Kono I. Reducing exercise-induced muscular injury in kendo athletes with supplementation of coenzyme Q10. British Journal of Nutrition. 2008;published online ahead of print.
Rosenfeldt FL, Pepe S, Linnane A, Nagley P, Rowland M, Ou R, Marasco S, Lyon W, Esmore D. "Improved outcomes in coronary artery bypass graft surgery with preoperative coenzyme Q10: a randomized, double-blind, placebo controlled trial." (In: "Coenzyme Q10 protects the aging heart against stress: studies in rats, human tissues, and patients."). Ann N Y Acad Sci 2002 Apr; 959: 355-9.
Singh RB, Wander GS, Rastogi A, Shukla PK, Mittal A, Sharma JP, Mehrotra SK, Kapoor R, Chopra RK. "Randomized, double-blind placebo-controlled trial of coenzyme Q10 in patients with acute myocardial infarction." Cardiovasc Drugs Ther. 1998 Sep; 12(4): 347-53.
Sacher HL, Sacher ML, Landau SW, Kersten R, Dooley F, Sacher A, Sacher M, Dietrick K, Ichkhan K. "The clinical and hemodynamic effects of coenzyme Q10 in congestive cardiomyopathy." Am J Ther. 1997 Feb-Mar; 4(2-3): 66-72.
Okuma K, Furuta I, Ota K. "Protective effect of coenzyme Q10 in cardiotoxicity induced by adriamycin." Gan To Kagaku Ryoho. 1984 Mar; 11(3): 502-8.
Baggio E, Gandini R, Plancher AC, et al. Italian multicenter study on the safety and efficacy of coenzyme Q10 as adjunctive therapy in heart failure. Mol Aspects Med. 1994; 15(Suppl):287-294.
Burke BE, Neuenschwander R, Olson RD. "Randomized, double-blind, placebo-controlled trial of coenzyme Q10 in isolated systolic hypertension." South Med J. 2001 Nov; 94(11): 1112-7.
AOR Hawthorn II
AOR Hawthorn
Hawthorn is considered the most important herb in the treatment of ischaemic heart disease and was shown to increase the force of myocardial contraction and coronary blood flow while reducing oxygen demand.
60 Vegi-Caps
AOR04223
100% Vegetarian
| SUPPLEMENT FACTS: Serving Size: 1 Capsule
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Non-medicinal ingredients:Capsule:hypromellose, water.
AOR™ guarantees that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, corn, nuts, dairy, soy, eggs, fish, shellfish or any animal byproducts.
Suggested Use:
Take 1 to 2 capsules per day with/without food or as directed by a qualified health care practitioner. Use for a minimum of two months to see beneficial effects.
Source:
Crataegus laevigata, leaves and flowers
Cautions:
Do not use if you are pregnant or nursing. Consult a health care practitioner prior to use if you are taking cardiac glycosides such as digitalis/digoxin, or blood pressure medication, or if symptoms persist or worsen.
Pregnancy/Nursing: Do not use
Main Applications:
Cardiovascular Health
Hypertension
AOR Hawthorn
Medical science is no longer obsessed only with finding newer and better drugs. Now, a lot of research is being done on old medicines, those that were traditionally passed down as remedies, but were never scientifically validated. Sometimes these experiments are surprisingly successful; other times the old stories turn out to be just that: stories. The story of hawthorn, though, is a success story.
Hawthorn (Crataegus laevigata) is a small thorny tree originally from Europe. For thousands of years, folk medicine has prescribed hawthorn for a variety of uses, from a sore throat to a troubled heart. Now, though, the evidence is in and it seems that, much as some of the stories said, hawthorn has overwhelmingly positive effects for the cardiovascular system.
It's Just So Much Chemistry
One thing science allows us to do is discover the molecular makeup of a plant, and then to predict some of its effects based on the plant's chemical composition. Hawthorn is a powerhouse of chemicals shown to help heart health. One such group of chemicals is the flavonoids found within hawthorn. Flavonoids are an unique type of health-giving substance found in plants. More and more science is suggesting that many of the benefits of a diet high in fruits and vegetables may derive from flavonoids, and not just the vitamins and minerals you get in such a diet.
The flavonoids in hawthorn have been shown to possess three distinct and significant effects that are particularly important to those worried about their heart health. Not only do they increase the resiliency of small blood vessels (important in reducing the risk of "bleeding" strokes), but these flavonoids also reduce atherosclerotic deposits and inhibit the activity of the angiotensin-converting enzyme (which increases blood pressure and is consequently targeted by heart drugs called "ACE inhibitors").
Apart from these valuable flavonoids, hawthorn also contains a number of other substances that have been indicated for improved heart health, such as amines, like o-methyloxyphenynylethylamine, phenethylamine, and isobutylamine, and triterpene acids, such as ursolate, oleanolate, and crategoleate. They may sound complicated and obscure, but some evidence, while not conclusive, suggests that they may be part of hawthorn's heart-healthy, herbal mixture.
Tried, Tested, and Effective
Hawthorn doesn't just contain heart-protective ingredients, it's also been tested extensively in human subjects. Chemistry is a complicated science and, without actual tests in humans, it can be difficult to discover if a substance that is useful by itself is also useful in a complicated formula, food, or herb. In humans, though, hawthorn's effects are just as promising as its chemical makeup indicates.
Researchers have discovered several properties of hawthorn of extreme importance to anyone concerned about the health of their heart. First among these is hawthorn's power to lower cholesterol. The liver is central to cholesterol circulation and hawthorn causes the liver to bind more LDL cholesterol, preventing it from reentering the blood stream, and to synthesize less LDL cholesterol in the first place. It also increases the excretion of cholesterol in the bile, causing lower levels of cholesterol in the blood where it can buildup into blood-flow-blocking deposits. At the same time, hawthorn extract has also been shown to prevent the accumulation of high blood lipids and fatty deposits in the liver and aorta, a key factor in atherosclerosis and a result of high cholesterol diets. Hawthorn is also well tolerated, has no known drug interactions, and has extremely low toxicity. All in all, hawthorn shows great potential for the safe and effective treatment of chronic heart failure.
Over a thousand patients with mild congestive heart failure (an inefficient heart, usually caused by years of high blood pressure, that leads to a buildup of fluid in the lungs) taking standardized hawthorn extract for six months experienced lower blood pressure and resting pulse rate, an increase in maximum exercise performance, and a decrease in depressed ST segments (an indicator of oxygen starvation) and arrhythmia. The researchers in this study found that hawthorn increased what is called ejection fracture, a measure of how fully the heart chambers are emptying themselves of blood with each beat. It also reduced nocturia (nighttime bathroom trips –a common, distressing symptom associated with CHF because of hypertension-induced kidney damage) and shin edema, also a classic symptom of congestive heart failure.
Other controlled trials have also shown that hawthorn has clear therapeutic benefits. One double-blind, placebo-controlled trial of hawthorn in subjects with mild CHF found that those receiving hawthorn showed improved exercise tolerance, fewer subjective symptoms, reductions in blood pressure (systolic and diastolic), and a healthier heart rate. Another trial comparing hawthorn with the blood-pressure lowering drug Captopril found similar significant improvements in exercise tolerance, reduced shin edema, and a large reduction in fatigue and shortness of breath.
Hawthorn has long been prescribed as a folk medicine. Now we have a probable explanation for this: because it works. Many traditional herbs and remedies are debunked when analyzed by science. However, hawthorn has gained notoriety as it is researched more for one simple reason; it's effective. If you want a natural approach to maintaining a healthy heart, then hawthorn is for you.
AOR Hawthorn
Hypotensive effects of hawthorn for patients with diabetes taking prescription drugs: a randomised contolled trial.
Br J Gen Pract. 2006 Jun;56(527):437-43.
Walker AF, Marakis G, Simpson E, Hope JL, Robinson PA, Hassanein M, Simpson HC.
BACKGROUND: Hawthorn (Crataegus laevigata) leaves, flowers and berries are used by herbal practitioners in the UK to treat hypertension in conjunction with prescribed drugs. Small-scale human studies support this approach.
AIM: To investigate the effects of hawthorn for hypertension in patients with type 2 diabetes taking prescribed drugs.
DESIGN OF STUDY: Randomised controlled trial.
SETTING: General practices in Reading, UK.
METHOD: Patients with type 2 diabetes (n = 79) were randomised to daily 1200 mg hawthorn extract (n = 39) or placebo (n = 40) for 16 weeks. At baseline and outcome a wellbeing questionnaire was completed and blood pressure and fasting blood samples taken. A food frequency questionnaire estimated nutrient intake.
RESULTS: Hypotensive drugs were used by 71% of the study population with a mean intake of 4.4 hypoglycaemic and/or hypotensive drugs. Fat intake was lower and sugar intake higher than recommendations, and low micronutrient intake was prevalent. There was a significant group difference in mean diastolic blood pressure reductions (P = 0.035): the hawthorn group showed greater reductions (baseline: 85.6 mmHg, 95% confidence interval [CI] = 83.3 to 87.8; outcome: 83.0 mmHg, 95% CI = 80.5 to 85.7) than the placebo group (baseline: 84.5 mmHg, 95% CI = 82 to 87; outcome: 85.0 mmHg, 95% CI = 82.2 to 87.8). There was no group difference in systolic blood pressure reduction from baseline (3.6 and 0.8 mmHg for hawthorn and placebo groups, respectively; P = 0.329). Although mean fat intake met current recommendations, mean sugar intake was higher and there were indications of potential multiple micronutrient deficiencies. No herb-drug interaction was found and minor health complaints were reduced from baseline in both groups.
CONCLUSIONS: This is the first randomised controlled trial to demonstrate a hypotensive effect of hawthorn in patients with diabetes taking medication.
Sunday, November 28, 2010
Monday, November 22, 2010
Jemieson Supplements
Jamieson Beta Carotene with C&E - 60 caps\
Jamieson Bilberry 2,500 mg - 60 capsules
Jamieson Biologics Menoflavon - Menopause Formula - 30 soft gel
Jamieson Biotin 250 mcg - 100 tablets
Jamieson Cal Magnesium Bonus
Jamieson Cal Magnesium with D Bonus -
Jamieson Calcium Mag/Zinc Bonus -
Jamieson Calcum with Vitamin D - 90 caplets
Jamieson Canadian Ginseng 250 mg - 60 caplets
Jamieson Chelated Chromium 200 mcg - 100 tablets
Jamieson Chewable Vitamin D 1000iu Chocolate - 100 tabs
Jamieson Chewable Vitamin D for Kids - Strawberry - 100 tabs
Jamieson Cholestanol TM - 60 caplets
Jamieson Co - Q10 30 mg - 60 soft ge
Jamieson Co Q 10 120 mg - 30
Jamieson Cod Liver Oil Caps - 100 soft gel
Jamieson CoQ10 100mg with Omega - 3 - 30 caps
Jamieson CoQ10 120mg Bonus - 30+15 caps
Jamieson CoQ10 250mg - 30 caps
Thursday, November 18, 2010
Jamieson Vitamins - Best Prices on Cureself.com
Jamieson 100% Pure Vitamin E Oil - 28 ml
Jamieson 100% Pure Vtiamin E Oil with Bonus Omega - 3 - 28ml/80 capsules
Jamieson Acidophilous Bonus - 100+30 caps
Jamieson Adults 50+ Vita Vim Bonus -
Jamieson Advanced 4 Strain - 60 caps
Jamieson Alfalfa 650 mg - 100 caplets
Jamieson Allicin Rich Garlic - 90 capsules
Jamieson Aloe Vera Soothing and Moisturizing Gel - 240 ml
Jamieson Arthrimin GS - Effervescent Drink Crystal Complex - 10 x 21 g
Jamieson Arthrimin GS - Glucosamine 750 mg - Shellfish Free - 150 caps
Jamieson Arthrimin GS - Glucosamine Chondroitin Complex - 60 capsules
Jamieson Arthrimin GS - Glucosamine Sulfate 500 mg - 150 capsules
Jamieson Arthrimin GS - Glucosamine Sulfate 500 mg - 300 caplets
Jamieson Arthrimin GS - MSM 1,000 mg - 90 caplets
Jamieson Arthrimin GS Glucasamine Chondroitin 500 mg - 180 caps
Jamieson Arthrimin GS Glucasamine Chondroitin 900 mg - 180 caplets
Jamieson Arthrimin GS Glucasamine Chondroitin MSM 1300 mg - 120 tabs
Jamieson Arthrimin GS Glucasamine Sulfate 500 mg - 360 caps
Jamieson B Complex 100 mg Timed Release - 60 caplets